Hartmut Jaeschke Selected Research

Oxidants (Oxidizing Agents)

3/2021	Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
12/2019	Emerging and established modes of cell death during acetaminophen-induced liver injury.
5/2018	Oxidant Stress and Lipid Peroxidation in Acetaminophen Hepatotoxicity.
2/2017	Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity.
12/2016	Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
12/2015	Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses.
9/2015	Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity.
7/2015	Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury.
6/2015	Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.
5/2015	Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Hartmut Jaeschke Research Topics

Disease

79	Necrosis 01/2022 - 02/2002
57	Acute Liver Failure (Fulminant Hepatic Failure) 05/2022 - 01/2010
49	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 02/2002
36	Inflammation (Inflammations) 01/2022 - 10/2003
23	Cholestasis 01/2020 - 04/2004
18	Chemical and Drug Induced Liver Injury 06/2021 - 11/2003
14	Liver Failure 01/2022 - 06/2002
11	Ischemia 01/2022 - 07/2002
11	Liver Diseases (Liver Disease) 01/2021 - 04/2004
11	Reperfusion Injury 01/2020 - 07/2002
6	Poisoning 01/2022 - 01/2015
6	Hemorrhage 01/2017 - 07/2002
6	Fibrosis (Cirrhosis) 06/2010 - 02/2006
5	Non-alcoholic Fatty Liver Disease 01/2022 - 02/2002
5	Hepatitis 01/2019 - 02/2002
5	Infarction (Infarctions) 01/2018 - 02/2006
4	Hepatocellular Carcinoma (Hepatoma) 09/2015 - 09/2005
3	Neoplasms (Cancer) 04/2021 - 11/2014
3	Drug-Related Side Effects and Adverse Reactions 12/2019 - 02/2012
3	Sclerosing Cholangitis 06/2010 - 02/2006
3	Endotoxemia 05/2005 - 01/2004
2	Pain (Aches) 01/2022 - 05/2019
2	Schizophrenia (Dementia Praecox) 01/2021 - 03/2019
2	Obesity 02/2016 - 09/2012
2	Body Weight (Weight, Body) 01/2016 - 05/2015
2	Infections 05/2015 - 12/2009
2	Hypoxia (Hypoxemia) 10/2010 - 06/2003

Drug/Important Bio-Agent (IBA)

127	Acetaminophen (Paracetamol)FDA LinkGeneric 05/2022 - 06/2002
33	Proteins (Proteins, Gene)FDA Link 01/2022 - 10/2005
30	Oxidants (Oxidizing Agents)IBA 03/2021 - 07/2002
22	Pharmaceutical PreparationsIBA 01/2022 - 01/2006
19	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2005
18	Alanine Transaminase (SGPT)IBA 01/2022 - 10/2002
17	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 02/2006
13	Peroxynitrous Acid (Peroxynitrite)IBA 01/2022 - 11/2002
13	Glutathione (Reduced Glutathione)IBA 03/2021 - 06/2002
9	Adenosine Triphosphate (ATP)IBA 05/2018 - 02/2002
8	antiarrhythmic peptide (AAP)IBA 11/2006 - 06/2002
7	Oxygen (Dioxygen)IBA 01/2017 - 07/2002
6	AntidotesIBA 01/2022 - 12/2015
6	JNK Mitogen-Activated Protein KinasesIBA 03/2021 - 01/2013
6	Acetylcysteine (Siran)FDA LinkGeneric 01/2021 - 11/2006
6	CaspasesIBA 08/2020 - 12/2011
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2015 - 05/2003
5	CytokinesIBA 04/2020 - 10/2003
5	XenobioticsIBA 03/2018 - 08/2007
5	Keratin-18 (Keratin 18)IBA 03/2018 - 01/2012
5	fas Receptor (CD95 Antigen)IBA 08/2013 - 06/2002
5	DNA (Deoxyribonucleic Acid)IBA 01/2012 - 10/2003
4	Superoxides (Superoxide)IBA 01/2022 - 07/2002
4	Phosphotransferases (Kinase)IBA 01/2022 - 03/2009
4	Transaminases (Aminotransferases)IBA 05/2017 - 08/2003
4	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 01/2017 - 01/2004
4	GalactosamineIBA 10/2016 - 07/2003
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2016 - 10/2006
4	EnzymesIBA 02/2016 - 02/2006
4	3-nitrotyrosineIBA 02/2011 - 01/2004
4	Glutathione Disulfide (GSSG)FDA LinkGeneric 07/2010 - 07/2002
3	Fomepizole (Antizol)FDA LinkGeneric 01/2022 - 01/2019
3	IronIBA 01/2022 - 11/2008
3	Protein Kinases (Protein Kinase)IBA 01/2022 - 12/2013
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2022 - 10/2010
3	N-acetyl-4-benzoquinoneimine (NAPQI)IBA 03/2021 - 01/2010
3	Caspase InhibitorsIBA 08/2020 - 05/2017
3	ChemokinesIBA 04/2020 - 10/2003
3	EndonucleasesIBA 12/2019 - 07/2015
3	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 01/2019 - 09/2012
3	AntioxidantsIBA 01/2019 - 07/2002
3	Mitochondrial DNA (mtDNA)IBA 10/2017 - 02/2002
3	Mitochondrial Proteins (Mitochondrial Protein)IBA 03/2016 - 03/2011
3	HMGB1 Protein (HMG1)IBA 03/2015 - 01/2012
3	MicroRNAs (MicroRNA)IBA 11/2014 - 07/2014
3	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 11/2014 - 10/2003
3	Heme Oxygenase-1IBA 07/2013 - 01/2004
3	3,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA 06/2010 - 08/2007
2	Methanol (Carbinol)IBA 01/2022 - 01/2019
2	Ethylene Glycol (Monoethylene Glycol)IBA 01/2022 - 01/2019
2	Analgesics (Analgesic Drugs)IBA 12/2021 - 08/2020
2	Cysteine (L-Cysteine)FDA Link 01/2021 - 06/2013
2	quinone (benzoquinone)IBA 12/2020 - 03/2016
2	IminesIBA 12/2020 - 03/2016
2	Mitochondrial Permeability Transition PoreIBA 12/2019 - 07/2010
2	Toll-Like Receptors (Toll-Like Receptor)IBA 10/2018 - 01/2012
2	ConnexinsIBA 08/2017 - 01/2016
2	Eosine Yellowish-(YS) (Eosin)IBA 05/2017 - 11/2014
2	Hematoxylin (Haematoxylon)IBA 05/2017 - 11/2014
2	Apoptosis Inducing FactorIBA 02/2017 - 12/2013
2	endonuclease GIBA 02/2017 - 11/2006
2	InflammasomesIBA 01/2017 - 05/2011
2	LipopolysaccharidesIBA 10/2016 - 01/2011
2	Furosemide (Lasix)FDA LinkGeneric 02/2016 - 02/2014
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2015 - 06/2015
2	deoxyuridine triphosphateIBA 11/2014 - 10/2003
2	Lithocholic AcidIBA 07/2014 - 02/2006
2	OsteopontinIBA 01/2014 - 06/2010
2	Matrix Metalloproteinases (MMPs)IBA 01/2014 - 08/2006
2	EndotoxinsIBA 12/2013 - 01/2004

Therapy/Procedure

8	Ligation 01/2020 - 10/2004
5	Liver Transplantation 01/2022 - 01/2003
4	Therapeutics 01/2016 - 02/2006